Antibiotic products



Patented Sept. 19, 1950 ANTIBIOIIC PRODUCTS David Libermann, Paris,France, assignor to Chimie & Atomistique, Paris, France, a Frenchcompany No Drawing. Application September 2, 1948, Serial No. 47,539. InFrance June 29, 1948 8 Claims.

The research work carried out by the applicant has Shown that the knownantibacterial activity of antibiotic products such as penicillin,streptomycin, thyrothricin, allicin and the like, can be considerablyincreased by causing these products to act in the presence of substancesof the thiouracil family, which exert a braking eilect upon theproduction of thyroxin and, conse quently, decrease the basicmetabolism.

The invention has for its object to provide improved antibiotic productswhich comprise a mixture of antibiotic substances and a thiounacil suchas, 6-propyl-thiouracil, G-benzyl-thiouracil andtetra-methylene-thiouraci].

In the case where the antibiotic substances are administered byintramuscular injection, thiouracils are added in the form of theirsodium salts, either dissolved in isotonic sodium chloride solutions, oras a powder added to penicillin or other antibiotic substance.

For example, 0.10 to 0.20 g. of sodium-B-benzylthiouracil or sodiumtetramethylene thiouracil may be added to 200,000 u. of penicillin.

Having now described my invention what I claim as new and desire tosecure by Letters Patcut is:

1. An improved antibiotic product comprising a mixture of an antibioticsubstance with a member of the thiouracil family.

2. A product as claimed in claim 1 wherein said antithyroidal substanceis G-benzyl-thiouracil.

3. A product as claimed in claim 1 wherein said antithyroidal substanceis tetra-methylene-thiouracil.

4. An improved antibiotic substance comprising a mixture of penicillinwith 6-benzy1-thiouracil.

5. A product as claimed in claim 1, wherein said thiouracil is added inthe form of a sodium salt dissolved in an isotonic sodium chloridesolution.

6. An antibiotic product comprising a mixture of penicillin andsodium-G-benzyl-thiouracil in the proportion of 0.10 to 0.20 g. ofsodium-6- benzyl-thiouracil to 200,000 units of penicillin, said sodiumbenzyl-thiounacil being in solution in an isotonic sodium chloridesolution.

7. An antibiotic product comprising a mixture of penicillin and sodiumtetra-methylene-thiouracil in the proportion of 0.10 to 0.20 g. ofsodium tetra-methylene-thiouracil to 200,000 units of penicillin, saidsodium tetra-methylene-thiouracil being in solution in an isotonicsodium chloride solution.

8. A product as claimed in claim 1 wherein said thiouracil is6-propyl-thiouracil.

DAVID LIBERMANN.

REFERENCES CITED The following references are of record in the file ofthis patent:

Thiouracii and Its Allies in the Treatment of Hyperthyroidism,"International Abstract of Surgery, Feb. 1948, pages to 123.

"Penicillin, Its Practical Application," Fleming (1946), P e 106.

1. AN IMPROVED ANTIBIOTIC PRODUCT COMPRISING A MIXTURE OF AN ANTIBIOTICSUBTANCE WITH A MEMBER OF THE THIOURACIL FAMILY.